HATU CAS 148893-10-1 is a common coupling reagent used in peptide synthesis and organic chemistry. Peptide Synthesis: HATU is widely used as a coupling reagent in peptide synthesis. It efficiently activates carboxyl groups (such as those found in amino acids protected as Fmoc or Boc derivatives) for amide bond formation with amino groups.- Coupling Reagent: HATU is used to couple amino acids or peptides to form peptide bonds in a variety of sequences and lengths.- Solid-Phase Peptide Synthesis (SPPS): HATU is particularly useful in SPPS, where it facilitates the attachment of amino acids to a solid support and ensures high coupling efficiency.- Solution-Phase Peptide Synthesis: In addition to SPPS, HATU can also be used in solution-phase peptide synthesis, where it facilitates the formation of peptide bonds in solution.- Synthesis of Peptide Mimetics: HATU can also be employed in the synthesis of peptide mimetics and peptidomimetics, which are compounds that mimic the structure and function of peptides but may have improved properties such as stability or bioavailability.- Modification of Peptides: HATU can also be used in the modification of peptides, such as introducing functional groups or labels onto peptide sequences.